Authors: Dongwen Wu, Catherine H. Poholek, Saikat Majumder, Qixing Liu, Shankar K. Revu, Kanishka Mohib, David M. Rothstein, Mandy J. McGeachy
Published: 2021-12-17
DOI: 10.1126/sciimmunol.aao3669
Source: Full article
Prior experience of pathogen-associated stimuli reduces morbidity and mortality to newly encountered infections through innate immune training, which can be enhanced by childhood vaccination. Fibroblastic reticular cells (FRCs) are stromal cells in lymphoid organs that support lymphocyte localization and survival and modulate adaptive immune responses. IL-17 signaling is important for FRC metabolism and proliferation during inflammatory responses. Here, we show that FRC-intrinsic IL-17 signaling was required for protective antibody-mediated immunity to the gut bacterial pathogen