Unstable regulatory T cells, enriched for naïve and Nrp1^negcells, are purged after fate challenge

Authors: Steffie Junius, Adamantios V. Mavrogiannis, Pierre Lemaitre, Margaux Gerbaux, Frederik Staels, Vanshika Malviya, Oliver Burton, Václav Gergelits, Kailash Singh, Raul Yhossef Tito Tadeo, Jeroen Raes, Stephanie Humblet-Baron, Adrian Liston, Susan M. Schlenner

Published: 2021-07-23

DOI: 10.1126/sciimmunol.abe4723

Source: Full article

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Abstract

Lymphophenic fate challenge purges incompletely committed regulatory T cells, a subset enriched for naïve neuropilin-1–negative Treg.