In vivo genome-wide CRISPR screens identify SOCS1 as intrinsic checkpoint of CD4

Authors: Aurélien Sutra Del Galy, Silvia Menegatti, Jaime Fuentealba, Francesca Lucibello, Laetitia Perrin, Julie Helft, Aurélie Darbois, Michael Saitakis, Jimena Tosello, Derek Rookhuizen, Marc Deloger, Pierre Gestraud, Gérard Socié, Sebastian Amigorena, Olivier Lantz, Laurie Menger

Published: 2021-12-03

DOI: 10.1126/sciimmunol.abe8219

Source: Full article

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Abstract

Inactivation of SOCS1 optimizes adoptive T cell therapy including human CAR-T cell composition and efficacy.