TRAF6 prevents fatal inflammation by homeostatic suppression of MALT1 protease

Authors: Thomas J. O’Neill, Thomas Seeholzer, Andreas Gewies, Torben Gehring, Florian Giesert, Isabel Hamp, Carina Graß, Henrik Schmidt, Katharina Kriegsmann, Marie J. Tofaute, Katrin Demski, Tanja Poth, Marc Rosenbaum, Theresa Schnalzger, Jürgen Ruland, Martin Göttlicher, Mark Kriegsmann, Ronald Naumann, Vigo Heissmeyer, Oliver Plettenburg, Wolfgang Wurst, Daniel Krappmann

Published: 2021-11-12

DOI: 10.1126/sciimmunol.abh2095

Source: Full article

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Abstract

TRAF6 maintains immune homeostasis by preventing deregulated activation of the MALT1 paracaspase in T cells.