Move over NAIP, DDX17 diversifies the NLRC4 inflammasome

Authors: Katherine C. Barnett, Kaixin Liang, Jenny P.-Y. Ting

Published: 2021-12-03

DOI: 10.1126/sciimmunol.abm1201

Source: Full article


Abstract

DDX17 binds short interspersed nuclear element RNAs to nucleate a dual NLRC4/NLRP3 inflammasome, highlighting the emerging role of endogenous ligands in NLRC4 activation (see the related Research Article by