EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody–Drug Conjugate HER3–DXd

Authors: Heidi M. Haikala, Timothy Lopez, Jens Köhler, Pinar O. Eser, Man Xu, Qing Zeng, Tyler J. Teceno, Kenneth Ngo, Yutong Zhao, Elena V. Ivanova, Arrien A. Bertram, Brittaney A. Leeper, Emily S. Chambers, Anika E. Adeni, Luke J. Taus, Mari Kuraguchi, Paul T. Kirschmeier, Channing Yu, Yoshinobu Shiose, Yasuki Kamai, Yang Qiu, Cloud P. Paweletz, Prafulla C. Gokhale, Pasi A. Jänne

Published: 2021-09-21

DOI: 10.1158/0008-5472.can-21-2426

Source: Full article


Abstract

Abstract