Authors: Tobias Wagner, Rudi Micheletti, Havilah Taylor, Yousin Suh, Michael G Rosenfeld, Alice E Zemljic-Harpf
Published: 2021-11-22
DOI: 10.1161/res.129.suppl_1.mp256
Source: Full article
Regulation of the geroprotective histone-deacetylase SIRT1 is an important physiological strategy to protect against cardiovascular disease. SIRT1 activity regulates the oxidative stress response, DNA damage pathways, cell death, and cardioprotective SIRT1 levels decreases with age. Based on this and GWAS studies implicating misregulation linked to myocardial infarction risk, we hypothesized that disrupting proximal promoter regulation of