The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/IL-33/type 2 innate immunity circuit

Authors: Yuli Lin, Liuling Xiao, Qian Cai, Cuisong Zhu, Shufen Li, Bingji Li, Ting Liu, Qiongyue Zhang, Yi Wang, Yiming Li, Xing He, Dongning Pan, Qiqun Tang, Xiaohui Wu, Weiqing Pan, Jiqiu Wang, Xi Li, Rui He

Published: 2021-07-30

DOI: 10.1126/sciimmunol.abg9698

Source: Full article

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Abstract

Chemerin restricts cold-induced IL-33 production by beige adipocytes, impairing beige fat’s ability to dissipate excess energy stores.