Authors: Daniel D Almeida Preto, Bruno Lordelo, Rosielly Melo Tavares, Nathália Gimenes Afonso, Hadson Silva Araujo, Joao Neif, Luis Eduardo Rosa Zucca, Flavio Mavignier Carcano
Published: 2022-06-06
DOI: 10.1200/jco.2022.40.16_suppl.e17017
Source: Full article
e17017 Background: Penile cancer is a rare disease worldwide, but in the developing countries represent 2% of male cancers, and sociocultural issues are closely related to risk. Lymph node status is a key prognostic factor, and almost 60% of patients has lymph node disease at diagnosis. Perioperative treatment for patients with regional lymph node disease is essential for a better outcome. Methods: We retrospectively reviewed all penile cancer patients, with histological confirmation, between 2009 and 2019 at Barretos Cancer Hospital (Brazil). Only squamous cell carcinoma that performed lymphadenectomy were included. Univariable analysis were performed to explore association between clinical and pathological features. Cumulative survival probabilities were calculated using the Kaplan-Meier method and differences between survivals were tested using the log-rank test. Results: One hundred and thirteen patients were eligible for analyses. The mean age was 55.7 year. Most of the patients were declared white, in a stable relationship and had a lower education level, with more than 70% of patients attending only elementary school. Clinical-pathological staging concordance was 43%. Overall survival was related to pathologic lymph node staging (pN), ranging from 111 months for pN0 individuals to 46.9 months for pN3 (p < .001). Considering only pN2-3 stages, only 54% of patients were submitted to adjuvant treatment and those had significantly improved 5 years cumulative survival, almost 50% versus 20% (p = .027). Only one patient was submitted to neoadjuvant therapy. Conclusions: The epidemiological profile matches with the current literature, reaffirming this public health issue in low-income countries. Accurated lymph node staging is essential to define the prognosis and an agressive multi-modality approach could improve results in the perioperative nodal metastatatic setting. Further prospective controlled studies should be stimulated in this context.