Authors: Yunxiao Zhang, Yizhi Zhang, Chen Ye, Xiaotian Qi, Li-Zhu Wu, Xiao Shen
Published: 2022-10-16
DOI: 10.1038/s41467-022-33730-x
Source: Full article
AbstractDeveloping photo-induced cascade cyclization of alkene-tethered acylsilanes is challenging, because acylsilanes are unstable under light irradiation. Herein, we report that the energy transfer from excited acylsilanes to a photocatalyst that possesses lower triplet energy can inhibit the undesired decomposition of acylsilanes. With neutral Eosin Y as the photocatalyst, an efficient synthesis of cyclopentanol derivatives is achieved with alkene-tethered acylsilanes and allylic sulfones. The reaction shows broad substrate scope and the synthetic potential of this transformation is highlighted by the construction of cyclopentanol derivatives which contain fused-ring or bridged-ring.