Authors: Katherine Z. Sanidad, Mohammed Amir, Aparna Ananthanarayanan, Anvita Singaraju, Nicholas B. Shiland, Hanna S. Hong, Nobuhiko Kamada, Naohiro Inohara, Gabriel Núñez, Melody Y. Zeng
Published: 2022-06-10
DOI: 10.1126/sciimmunol.abh3816
Source: Full article
The gut microbiome elicits antigen-specific immunoglobulin G (IgG) at steady state that cross-reacts to pathogens to confer protection against systemic infection. The role of gut microbiome–specific IgG antibodies in the development of the gut microbiome and immunity against enteric pathogens in early life, however, remains largely undefined. In this study, we show that gut microbiome–induced maternal IgG is transferred to the neonatal intestine through maternal milk via the neonatal Fc receptor and directly inhibits