Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation

Authors: Zhian Chen, Yanfang Cui, Yin Yao, Bo Liu, Joseph Yunis, Xin Gao, Naiqi Wang, Pablo F. CaƱete, Zewen Kelvin Tuong, Hongjian Sun, Hao Wang, Siling Yang, Runli Wang, Yew Ann Leong, David Simon Davis, Jiahuan Qin, Kaili Liang, Jun Deng, Conan K. Wang, Yen-Hua Huang, Jonathan A. Roco, Sam Nettelfield, Huaming Zhu, Huajun Xu, Zhijia Yu, David Craik, Zheng Liu, Hai Qi, Christopher Parish, Di Yu

Published: 2023-02-17

DOI: 10.1126/sciimmunol.add1728

Source: Full article


Abstract

In antibody responses, mutated germinal center B (B