Authors: Agnieszka M. Kabat, Alexandra Hackl, David E. Sanin, Patrice Zeis, Katarzyna M. Grzes, Francesc Baixauli, Ryan Kyle, George Caputa, Joy Edwards-Hicks, Matteo Villa, Nisha Rana, Jonathan D. Curtis, Angela Castoldi, Jovana Cupovic, Leentje Dreesen, Maria Sibilia, J. Andrew Pospisilik, Joseph F. Urban, Dominic Grün, Erika L. Pearce, Edward J. Pearce
Published: 2022-10-14
DOI: 10.1126/sciimmunol.add3263
Source: Full article
Type 2 immunity is associated with adipose tissue (AT) homeostasis and infection with parasitic helminths, but whether AT participates in immunity to these parasites is unknown. We found that the fat content of mesenteric AT (mAT) declined in mice during infection with a gut-restricted helminth. This was associated with the accumulation of metabolically activated, interleukin-33 (IL-33), thymic stromal lymphopoietin (TSLP), and extracellular matrix (ECM)–producing stromal cells. These cells shared transcriptional features, including the expression of