Authors: Xinrui Wang, Katherine Kulik, Tina C Wan, Amelia Lauth, John W Lough, John A Auchampach
Published: 2022-11-14
DOI: 10.1161/res.131.suppl_1.p1011
Source: Full article
In recent decades, many cardiovascular diseases have been ascribed to acetylation-dependent regulatory mechanisms, as revealed by the beneficial effects of targeting de-acetylase proteins. By contrast, we are targeting the acetyltransferase Tip60 (Tat-interactive protein 60 kD), a pleiotropic tumor suppressor encoded by the