Authors: Shridhar Sanghvi, Divya Sridharan, Vincenzo Trovato, Sakima Smith, Mahmood Khan, Harpreet Singh
Published: 2022-11-14
DOI: 10.1161/res.131.suppl_1.p2097
Source: Full article
Ischemic heart disease (IHD) is one of the leading causes of death related due to heart failure (HF). It is mainly characterized by impairment of heart contraction-relaxation (rhythmicity) and cardiac output. While a myriad of cellular processes is associated with IHD, one of the major cellular aspects strongly associated is the electrolyte and ionic imbalance. Serum sodium levels have been a well-established adverse prognostic marker for patients with chronic heart failure. Recent evidences have suggested that the lower serum chloride (hypochloremia, <90mM) is associated with increased mortality risk in patients with chronic HF independent of serum sodium levels. Serum chloride (Cl