Authors: Justin M Quiles, Liguo Chi, Rita H Najor, Åsa B Gustafsson
Published: 2022-11-14
DOI: 10.1161/res.131.suppl_1.p3033
Source: Full article
Alpha-B-crystallin (CryAB) is an abundant molecular chaperone comprising nearly 5% of total cardiac mass. While predominately cytosolic, some studies note mitochondrial translocation of CryAB during stress. The autosomal dominant R120G mutation leads to CryAB misfolding and protein aggregation resulting in cardiomyopathy. Although mitochondrial dysfunction has been reported in cardiac-specific CryAB