Authors: Wendong Liu, Enyu Shi, Hao Wu, Yanjie Liang, Mingyue Chen, Hongyan Zhang, Ruizhong Zhang, Xiyan Li, Yinsong Wang, Libing Zhang
Published: 2024-05-03
Source: Full article
AbstractSingle‐atom nanozymes (SAzymes) have made significant strides in antibacterial treatment but fall short as natural enzyme and drug replacements due to limited catalytic performance. Here, a rational strategy is presented for incorporating spatially axial boron (B) ligands to effectively modulate the local coordination environment of planar Fe─N4 motifs (Fe─B/N─C SAzymes). With electronic modulation, the Fe─B/N─C SAzymes exhibit significantly enhanced oxidase‐, peroxidase‐, and catalase‐like activities. Theoretical calculations highlight that the spatially axial B ligands effectively adjust the charge distribution around the planar Fe─N4 active center, which facilitates the heterolysis of H2O2 and the desorption of O2, resulting in accelerated H2O2 decomposition. Furthermore, the intrinsic photothermal effect of Fe─B/N─C SAzymes enhances multienzyme‐like activities, rapidly generating abundant reactive oxygen species (ROS), and achieving chemodynamic/photothermal synergistic therapy for impressive disinfection against periodontal‐related pathogenic bacteria. These findings offer a distinctive viewpoint for optimizing the local coordination environment of SAzymes with axial ligand to enhance their catalytic performance and effectiveness in periodontitis therapy.