Shorter Is Better: The α-(<scp>l</scp>)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs

Authors: Shigeo Matsuda, Saikat Bala, Jen-Yu Liao, Dhrubajyoti Datta, Atsushi Mikami, Lauren Woods, Joel M. Harp, Jason A. Gilbert, Anna Bisbe, Rajar M. Manoharan, MaryBeth Kim, Christopher S. Theile, Dale C. Guenther, Yongfeng Jiang, Saket Agarwal, Rajanikanth Maganti, Mark K. Schlegel, Ivan Zlatev, Klaus Charisse, Kallanthottathil G. Rajeev, Adam Castoreno, Martin Maier, Maja M. Janas, Martin Egli, John C. Chaput, Muthiah Manoharan

Published: 2023-08-28

DOI: 10.1021/jacs.3c04744

Source: Full article

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Abstract

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