Authors: Michelle Di Paola, Cristine Reitz, Uros Kuzmanov, Kateleen Jia, Allen Teng, Anthony Gramolini
Published: 2023-10-13
DOI: 10.1161/res.133.suppl_1.p1027
Source: Full article
The sarco(endo)plasmic reticulum (SR/ER) is an essential regulator of many key cellular processes, especially those that play a role in the development and progression of cardiac disease. However, many aspects of its structural organization remain poorly defined. Receptor Expression Enhancing Protein 5 (REEP5) is a cardiac enriched SR/ER membrane protein, which regulates organization of the highly differentiated SR/ER network and responses to stress. In zebrafish models, genetic knock-out of