Authors: Jordy M Kocken, Pedro Mendes-Ferreira, Henry del Marmol, Tim Davalan, Raquel Figuinha Videira, Adelino F Leite-Moreira, Paula A da Costa Martins
Published: 2023-10-13
DOI: 10.1161/res.133.suppl_1.p2044
Source: Full article
Pulmonary arterial hypertension (PAH) is a rare disease that includes familiar and idiopathic forms. Increased pressure in the pulmonary artery leads to pressure overload of the right ventricle (RV) and subsequent hypertrophic remodeling to maintain cardiac output (CO). While many therapies are available for the hypertrophic left ventricle (LV), the RV is known to involve distinct remodeling pathways and unfortunately, these are poorly understood, and no cure is available. To identify new regulatory mechanisms, total RNA sequencing was performed on hypertrophied mouse RV tissue. Focusing at differentially expressed long non-coding RNAs (lncRNAs), one specifically,