Abstract P2048: New Insights Into The Role Of The Glycocalyx Components In Heart Failure Induced By Pressure Overload.

Authors: Lakshmi Narasimha Thota, Simone Potje, Lusiane Bendhack, Joao Carvalho-de-Souza, Andreia Chignalia

Published: 2023-10-13

DOI: 10.1161/res.133.suppl_1.p2048

Source: Full article

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Abstract

Heart failure (HF) is a complex disease with multifactorial etiology. The degradation of the glycocalyx is a process thought to contribute to the progression of HF. The relative individual contribution of glycocalyx components to HF progression is unclear. Previous studies have shown that the expression of glypican 1 (Gpc1), a glycocalyx component, is reduced after aortic banding. Herein, we sought to determine if Gpc1 participates in the progression of HF induced by pressure overload and the associated mechanisms.