Abstract P3046: The Effect Of MicroRNA-367-3p And MicroRNA-148a-3p On Vascular Endothelial Cells In Context Of Senescence And Infarct Healing

Authors: Laura Hehl, Katrin Kalies, Fiene Daniel, Kai Knoepp, Jochen Dutzmann, Daniel SEDDING, Jan Michael Köster, Simon Guerlach, Solveig Boettcher

Published: 2023-10-13

DOI: 10.1161/res.133.suppl_1.p3046

Source: Full article

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Abstract

To improve the healing after myocardial infarction (MI), a well-coordinated angiogenic response is necessary. MicroRNAs (miRNAs) were identified as regulators of angiogenesis, however, strategies to improve angiogenesis by targeting miRNAs are challenging. Here, we evaluate miRNA-367-3p and 148a-3p as novel miRNA candidates regarding their therapeutic potential toward neovascularization after MI.