CRISPR/Cas9 nickase mediated signal amplification integrating with the trans-cleavage activity of Cas12a for highly selective and sensitive detection of single base mutations

Authors: Xiao-Wen Fan, Zi-Fan Gao, Dong-Dong Ling, De-Hui Wang, Ying Cui, Hui-Qun Du, Chun-Lin Li, Xing Zhou

Published: 2024-04-23

DOI: 10.1186/s40779-024-00530-x

Source: Full article

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Abstract

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