Authors: Ningning Wang, Andres Merits, Michael Veit, Laura Sandra Lello, Shuhan Kong, Houqi Jiao, Jie Chen, Yu Wang, Georgi Dobrikov, Félix A. Rey, Shuo Su
Published: 2024-06-08
DOI: 10.1038/s41467-024-49301-1
Source: Full article
AbstractVarious low-density lipoprotein receptors (LPRs) have been identified as entry factors for alphaviruses, and structures of the corresponding virion-receptor complexes have been determined. Here, we analyze the similarities and differences in the receptor binding modes of multiple alphaviruses to understand their ability to infect a wide range of hosts. We further discuss the challenges associated with the development of broad-spectrum treatment strategies against a diverse range of alphaviruses.