Proteostasis and lysosomal repair deficits in transdifferentiated neurons of Alzheimer’s disease

Authors: Ching-Chieh Chou, Ryan Vest, Miguel A. Prado, Joshua Wilson-Grady, Joao A. Paulo, Yohei Shibuya, Patricia Moran-Losada, Ting-Ting Lee, Jian Luo, Steven P. Gygi, Jeffery W. Kelly, Daniel Finley, Marius Wernig, Tony Wyss-Coray, Judith Frydman

Published: 2025-03-26

DOI: 10.1038/s41556-025-01623-y

Source: Full article


Abstract

Abstract