The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect

Authors: Nancy Klemm, Roman R. Schimmer, Nils K. Konrad, Flavian Thelen, Jonas Fullin, Ebru Topçu, Christian Koch, Milena Treacy, Matthew Joseph Leventhal, Marco M. Bühler, Veronika Lysenko, Alexandre P.A. Theocharides, Kari J. Kurppa, Stefan Balabanov, Tuncay Baubec, Andrei V. Krivtsov, Peter G. Miller, Scott A. Armstrong, Benjamin L. Ebert, Markus G. Manz, Cesar Nombela-Arrieta, Steffen Boettcher

Published: 2025-03-31

DOI: 10.1158/0008-5472.can-24-1136

Source: Full article

The Prolonged Half-Life of the p53 Missense Variant R248Q Promotes Accumulation and Heterotetramer Formation with Wild-Type p53 to Exert the Dominant-Negative Effect

Abstract