A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer

Authors: Yanchao Yu, Xincheng Gao, Huayuan Zhao, Jiayin Sun, Miao Wang, Xing Xiong, Junping Li, Chao Huang, Hui Zhang, Guosong Jiang, Xingyuan Xiao

Published: 2025-03-25

DOI: 10.1158/0008-5472.can-24-3217

Source: Full article

A Genome-Wide Synthetic Lethal Screen Identifies Spermidine Synthase as a Target to Enhance Erdafitinib Efficacy in FGFR-Mutant Bladder Cancer

Abstract