Authors: Thirupura S Shankar, Marco Marchetti, Harini Srinivasan, J Ty Lunde, Craig Selzman, Edgar Javier Hernandez, Martin Tristani-Firouzi, Stavros Drakos, Omar Wever-Pinzon
Published: 2024-10-09
DOI: 10.1161/res.135.suppl_1.mo047
Source: Full article
Heart failure (HF) involves global genome modifications. Adverse structural and function remodeling that occurs in HF was initially considered to be irreversible. However, ~15% of HF patients on left ventricular assist device (LVAD) support show significant structural and functional reverse remodeling, distinguishing them as responders (R), while ~85% are non-responders (NR). DNA methylation and transcriptional changes that exert myocardial recovery is not well understood.