Authors: Tanner Monroe, Lorenzo pesce, Samuel Kearns, Lisa Dellefave-Castillo, Gregory Webster, Megan Puckelwartz, Elizabeth McNally
Published: 2024-10-09
DOI: 10.1161/res.135.suppl_1.mo076
Source: Full article
Background: Nonischemic sudden cardiac death (SCD) is a catastrophic cardiac rhythm failure. Heritable arrhythmias and cardiomyopathies contribute significantly to SCD risk, and genetic markers can be used to identify and reduce risk, improving odds of survival. Clinically, genetic evaluation of known rare risk variants using gene panels often fails to identify a genetic etiology. These gene panels focus on genes affiliated with monogenic inheritance, and current genetic analysis is agnostic to polygenic disease architectures.