Authors: Zhen Li, Jake Doiron, Huijing Xia, Kyle LaPenna, Thomas Sharp, Xiaoman YU, Noriyuki Nagahara, Traci Goodchild, David Lefer
Published: 2024-10-09
DOI: 10.1161/res.135.suppl_1.mo101
Source: Full article
Background: Heart failure with preserved ejection fraction (HFpEF) is among the leading causes of cardiovascular mortality and morbidity. Recent multi-omics data sets underscore severely impaired branched-chain amino acid (BCAA) catabolism in the failing hearts of HFpEF patients. 3-mercaptopyruvate sulfurtransferase (3-MST) is a mitochondrial hydrogen sulfide (H2S) synthase that regulates mitochondrial biogenesis, function, and substrate metabolism.