Abstract Or106: DNA Double-stranded Breaks, a Hallmark of Aging, Defined at the Nucleotide Resolution, Are Increased and Associated with Transcription in the Cardiac Myocyte Genome in LMNA-Cardiomyopathy

Authors: Benjamin Cathcart, Sirisha Marreddy, Leila Rouhi, Zhongming Zhao, Priyatansh Gurha, Ali Marian

Published: 2024-10-09

DOI: 10.1161/res.135.suppl_1.or106

Source: Full article

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Abstract

Background: An intrinsic feature of gene transcription is the formation of DNA superhelices near the transcription bubble, which are resolved upon induction of transient double-stranded breaks (DSBs) by topoisomerases. Unrepaired DSBs are pathogenic as they lead to cell cycle arrest, senescence, inflammation, and organ dysfunction.