Abstract Tu055: Prominent effects of p38 MAPK inhibition on the phosphoproteome of a guinea pig model of heart failure and sudden cardiac death

Authors: Sogol Sedighi, Ting Liu, Brian O’Rourke, D Foster

Published: 2024-10-09

DOI: 10.1161/res.135.suppl_1.tu055

Source: Full article

---

Abstract

Introduction: The p38 mitogen-activated protein kinase (p38 MAPK), activated by stress, plays a role in cardiac hypertrophy and heart failure (HF). The precise mechanism of action of p38 MAPK remains unclear, which could explain the mixed outcomes in P38 inhibitor trials. Here, we examine the impact of p38 MAPK inhibition on cardiac function and the proteome/phosphoproteome of the failing heart.