Authors: Siqi Li, Enrique Avila, Anna Berthiaume, Katelyn Albrecht, Chun Liu, Lu Han
Published: 2024-10-09
DOI: 10.1161/res.135.suppl_1.we030
Source: Full article
Mammalian cardiomyocytes undergo a loss of proliferative capacity due to cell division failure, leading to polyploidy (genome duplication) during postnatal maturation. Centrosomes, primary microtubule organizing centers (MTOCs) in animal cells comprised of centrioles and pericentriolar matrix (PCM), play a crucial role in cell division. In differentiated cells, non-centrosomal (nc) MTOCs can reorganize microtubules, with cellular localization varying between cell types to mediate specialized functions. The specific role of ncMTOCs in cardiomyocyte division and maturation remains unknown.