Authors: Maegan Brockman, Lanfang Wang, Triniti Scruggs, John Calvert, Rebecca Levit
Published: 2024-10-09
DOI: 10.1161/res.135.suppl_1.we064
Source: Full article
Introduction: Inflammation following myocardial ischemia/reperfusion injury (MI/R) plays a significant role in damaging cardiomyocytes and influencing infarct size, with neutrophils being the most rapid and numerous cells recruited to the myocardium post reperfusion. Single-cell RNA sequencing data identified neutrophils with upregulated type I interferon (IFN) signaling in the hearts of mice 24 hours post-MI/R.