Authors: Caitlin Howard, Emma Pendergraft, Sarah Belcher, Steven Jones
Published: 2024-10-09
DOI: 10.1161/res.135.suppl_1.we074
Source: Full article
Background: Following myocardial infarction, macrophages clear cellular debris during remodeling of the extracellular matrix (ECM). The presence of macrophages coincides with a significant increase in the ECM component hyaluronan (HA). HA is produced in copious amounts following injury, such as myocardial infarction, and HA may interfere with myocardial wound healing. Because macrophages express hyaluronan receptors and are known to facilitate ECM remodeling, it is possible that macrophages remove HA early after MI. The extent to which macrophages clear HA is not known.