Abstract We132: Genetic Blockade of PKA-mediated Phosphoregulation of 26S Proteasomes Exacerbates Pathology in Both the Brain and Heart of an Alzheimer’s Disease Model

Authors: Saima Ejaz, Jack Sternburg, Hongmin Wang, Rezvani Khosrow, Xuejun Wang

Published: 2024-10-09

DOI: 10.1161/res.135.suppl_1.we132

Source: Full article

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Abstract

Background: Alzheimer’s disease (AD) patients often display not only cognitive impairment but also cardiac malfunction, but the underlying factors remain elusive. Phosphorylation of Ser14 of RPN6 (p-S14-RPN6) is required for cAMP/protein kinase A (PKA) to activate 26S proteasomes. Proteasome priming is implicated in the protection by cAMP-PKA augmentation against AD, but this remains to be established. Hence, we conducted this study to address these critical gaps.