Chemoproteomic methods for covalent drug discovery

Authors: Wai Cheung Chan, Shabnam Sharifzadeh, Sara J. Buhrlage, Jarrod A. Marto

Published: 2021-06-18

DOI: 10.1039/d1cs00231g

Source: Full article


Abstract

The past decade has witnessed growing enthusiasm for covalent drug discovery. We review foundational and cutting-edge mass spectrometry chemoproteomic methods for covalent drug discovery: target ID, hit discovery, and lead characterization.