LKB1 specifies neural crest cell fates through pyruvate-alanine cycling

Authors: Anca G. Radu, Sakina Torch, Florence Fauvelle, Karin Pernet-Gallay, Anthony Lucas, Renaud Blervaque, Véronique Delmas, Uwe Schlattner, Laurence Lafanechère, Pierre Hainaut, Nicolas Tricaud, Véronique Pingault, Nadège Bondurand, Nabeel Bardeesy, Lionel Larue, Chantal Thibert, Marc Billaud

Published: 2019-07-17

DOI: 10.1126/sciadv.aau5106

Source: Full article

---

Abstract

Glial specification of neural crest cells requires the tumor suppressor LKB1-mediated action on alanine biosynthesis.