Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7

Authors: Scott McComb, Pik Ki Chan, Anna Guinot, Holmfridur Hartmannsdottir, Silvia Jenni, Maria Pamela Dobay, Jean-Pierre Bourquin, Beat C. Bornhauser

Published: 2019-07-31

DOI: 10.1126/sciadv.aau9433

Source: Full article

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Abstract

Caspase-3 and -7 are redundantly required to amplify the extrinsic and intrinsic apoptotic cascade in human leukemia.