Reciprocal regulation of TORC signaling and tRNA modifications by Elongator enforces nutrient-dependent cell fate

Authors: Julie Candiracci, Valerie Migeot, Yok-Hian Chionh, Fanelie Bauer, Thomas Brochier, Brandon Russell, Kazuhiro Shiozaki, Peter Dedon, Damien Hermand

Published: 2019-06-19

DOI: 10.1126/sciadv.aav0184

Source: Full article

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Abstract

A feedback control is operating between TOR complex (TORC) signaling and tRNA modification by Elongator to enforce cell fate.