Sortilin gates neurotensin and BDNF signaling to control peripheral neuropathic pain

Authors: Mette Richner, Lone T. Pallesen, Maj Ulrichsen, Ebbe T. Poulsen, Thomas H. Holm, Hande Login, Annie Castonguay, Louis-Etienne Lorenzo, Nádia P. Gonçalves, Olav M. Andersen, Karin Lykke-Hartmann, Jan J. Enghild, Lars C. B. Rønn, Ibrahim J. Malik, Yves De Koninck, Ole J. Bjerrum, Christian B. Vægter, Anders Nykjær

Published: 2019-06-19

DOI: 10.1126/sciadv.aav9946

Source: Full article

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Abstract

Blocking of sortilin ligand binding prevents neuropathic pain by inhibiting BDNF-induced spinal KCC2 down-regulation.