Inflammation up-regulates cochlear expression of TRPV1 to potentiate drug-induced hearing loss

Authors: Meiyan Jiang, Hongzhe Li, Anastasiya Johnson, Takatoshi Karasawa, Yuan Zhang, William B. Meier, Farshid Taghizadeh, Allan Kachelmeier, Peter S. Steyger

Published: 2019-07-17

DOI: 10.1126/sciadv.aaw1836

Source: Full article

---

Abstract

The nonselective cation channel TRPV1 is required for systemic inflammation to enhance aminoglycoside-induced hearing loss.