Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease

Authors: Yongzhan Sun, Zhiheng Liu, Xinyi Cao, Yi Lu, Zeyun Mi, Chaoran He, Jing Liu, Zhanye Zheng, Mulin Jun Li, Tiegang Li, Dechao Xu, Ming Wu, Ying Cao, Yuhao Li, Baoxue Yang, Changlin Mei, Lirong Zhang, Yupeng Chen

Published: 2019-06-05

DOI: 10.1126/sciadv.aaw3593

Source: Full article

---

Abstract

P-TEFb activation by cAMP-PKA signaling promotes cystogenic gene transcription elongation and disease progression in ADPKD.