Charge-switchable polymeric complex for glucose-responsive insulin delivery in mice and pigs

Authors: Jinqiang Wang, Jicheng Yu, Yuqi Zhang, Xudong Zhang, Anna R. Kahkoska, Guojun Chen, Zejun Wang, Wujin Sun, Lulu Cai, Zhaowei Chen, Chenggen Qian, Qundong Shen, Ali Khademhosseini, John B. Buse, Zhen Gu

Published: 2019-07-10

DOI: 10.1126/sciadv.aaw4357

Source: Full article

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Abstract

A glucose-responsive insulin-polymer complex for self-regulated insulin release has been verified in diabetic mice and minipigs.