Experimental evidence for the age dependence of tau protein spread in the brain

Authors: Susanne Wegmann, Rachel E. Bennett, Louis Delorme, Ashley B. Robbins, Miwei Hu, Danny MacKenzie, Molly J. Kirk, Julia Schiantarelli, Nahel Tunio, Ana C. Amaral, Zhanyun Fan, Samantha Nicholls, Eloise Hudry, Bradley T. Hyman

Published: 2019-06-26

DOI: 10.1126/sciadv.aaw6404

Source: Full article

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Abstract

We observed enhanced tau spreading in the aging mouse brain and tau misfolding in brain regions vulnerable in Alzheimer’s disease.