ITGA5 inhibition in pancreatic stellate cells attenuates desmoplasia and potentiates efficacy of chemotherapy in pancreatic cancer

Authors: Praneeth R. Kuninty, Ruchi Bansal, Susanna W. L. De Geus, Deby F. Mardhian, Jonas Schnittert, Joop van Baarlen, Gert Storm, Maarten F. Bijlsma, Hanneke W. van Laarhoven, Josbert M. Metselaar, Peter J. K. Kuppen, Alexander L. Vahrmeijer, Arne Östman, Cornelis F. M. Sier, Jai Prakash

Published: 2019-09-04

DOI: 10.1126/sciadv.aax2770

Source: Full article

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Abstract

This study proposes a novel strategy to reduce fibrotic barrier and enhance efficacy of chemotherapy in pancreatic cancer.