Structure and mechanism of bactericidal mammalian perforin-2, an ancient agent of innate immunity

Authors: Tao Ni, Fang Jiao, Xiulian Yu, Saša Aden, Lucy Ginger, Sophie I. Williams, Fangfang Bai, Vojtěch Pražák, Dimple Karia, Phillip Stansfeld, Peijun Zhang, George Munson, Gregor Anderluh, Simon Scheuring, Robert J. C. Gilbert

Published: 2020-01-30

DOI: 10.1126/sciadv.aax8286

Source: Full article

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Abstract

Bactericidal perforin-2 assembles an inactivated pre-pore complex and undergoes a 180° reconfiguration for membrane attack.