In situ recruitment of regulatory T cells promotes donor-specific tolerance in vascularized composite allotransplantation

Authors: James D. Fisher, Wensheng Zhang, Stephen C. Balmert, Ali M. Aral, Abhinav P. Acharya, Yalcin Kulahci, Jingjing Li, Heth R. Turnquist, Angus W. Thomson, Mario G. Solari, Vijay S. Gorantla, Steven R. Little

Published: 2020-03-13

DOI: 10.1126/sciadv.aax8429

Source: Full article

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Abstract

CCL22-releasing microparticles recruit suppressive immune cells to transplanted rat limbs to promote long-term graft survival.