Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion

Authors: Jason R. Plemel, Jo Anne Stratton, Nathan J. Michaels, Khalil S. Rawji, Eric Zhang, Sarthak Sinha, Charbel S. Baaklini, Yifei Dong, Madelene Ho, Kevin Thorburn, Timothy N. Friedman, Sana Jawad, Claudia Silva, Andrew V. Caprariello, Vahid Hoghooghi, Julie Yue, Arzina Jaffer, Kelly Lee, Bradley J. Kerr, Raj Midha, Peter K. Stys, Jeff Biernaskie, V. Wee Yong

Published: 2020-01-16

DOI: 10.1126/sciadv.aay6324

Source: Full article


Abstract

Microglia respond to white matter injury with different populations that prevent macrophage dispersion into spared tissue.