Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice

Authors: Takefumi Yamaguchi, Kazunari Higa, Yukari Yagi-Yaguchi, Koji Ueda, Hisashi Noma, Shinsuke Shibata, Toshihiro Nagai, Daisuke Tomida, Ririko Yasu-Mimura, Osama Ibrahim, Ryo Matoba, Kazuo Tsubota, Pedram Hamrah, Jun Yamada, Kohsuke Kanekura, Jun Shimazaki

Published: 2020-05-13

DOI: 10.1126/sciadv.aaz5195

Source: Full article

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Abstract

Pathological aqueous humor associated with iris atrophy leads to loss of corneal endothelial cells and corneal graft failure.